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This article, by Aidan Long, M.D., from the New England Journal of Medicine, has some interesting medical information about IgE isotypes and the possible connection of exposure plus a genetic predisposition for the reaction to allergens. It also has some good information and an illustration about the reaction of antigens within mast cells. Long, Aidan. “The Nuts and Bolts of Peanut Allergy.” New England Journal of Medicine, vol. 346, no. 17, 2002, pp. 1320–1322., https://doi.org/10.1056/nejm200204253461712.